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Position:
Director/Senior Director, DMPK

Employer:
Cytokinetics

Description:

As a condition of employment at Cytokinetics, employees are required to provide documentation of their COVID-19 vaccination record on their first day of employment. If you are unable to be vaccinated due to a medical restriction, or sincerely held religious belief, please contact Human Resources to request an exemption via the Company’s reasonable accommodation process.

 

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing next-in-class muscle activators and best-in-class muscle inhibitors as potential treatments for debilitating diseases in which muscle performance is compromised and/or declining. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact muscle function, contractility, and energetics. We take a purpose-driven approach by leveraging our unique muscle biology expertise to engineer compounds with specific characteristics aimed at treating diseases that impact muscle function, like heart failure, hypertrophic cardiomyopathy, ALS and SMA.

We view our employees as the unequivocal ingredients to success. Each and every employee is an integral member of the Cytokinetics team, contributing to our shared goal of improving lives. While expectations of our employees are high, there is an equal commitment to ensuring that contributions are recognized and rewarded. We seek exceptional individuals to join us in our mission to develop potential medicines to improve the healthspan of people with cardiovascular and neuromuscular diseases of impaired muscle function.

 

Cytokinetics is seeking an outstanding individual and scientist to lead our DMPK Department, including responsibilities for research DMPK and Clinical bio-analysis. This is an opportunity to build, lead and mentor a diverse team of scientists! Your team will be responsible for designing, implementing, and interpreting insightful in vitro and in vivo studies to explore adsorption, distribution, metabolism and excretion and understanding of how to align pharmacokinetics and pharmacodynamics to move research projects into drug candidates.

The Director/Sr. Director will develop scientific strategies, engage teammates across functions and build partnerships to advance Cytokinetics research and clinical development stage programs.

Responsibilities

  • Design and implement strategy across the department (project, people, space, equipment, systems, and work processes) for the support for all Discovery projects.
  • Responsible for the quality and performance of all DMPK and ADME activities including interactions with CRO's and internal project partners.
  • Create the vision for DMPK and ADME at Cytokinetics and craft our long-term strategic and operational model to support our growing research and development portfolio.
  • Participate in study design, vendor selection, study execution, interpretation and report writing for molecules that pertain to PK and PK/PD assessment Provide assistance with in-depth quality review and interpretation of results.
  • Establish and manage in vitro-in vivo correlations and use these correlations in collaboration with Pharmacology to project pre-clinical and clinical doses
  • Collaborate with other scientific disciplines including Medicinal Chemistry, Muscle Biology, Pharmacology, CMC, and Pre-Clinical and Clinical Development.
  • Transfer methods and protocols to CMC, pre-clinical and clinical development and collaborate in refinement activities when required.
  • Resolve highly sophisticated business and scientific problems through excellent scientific judgment and broad research, development, and regulatory affairs knowledge.
  • Manage department budget, including laboratory supplies, external research grants, capital expenditures, contract research personnel and projects, and external project spending.
  • Extensive knowledge of preclinical drug development and the preparation of regulatory documents, e.g. INDs and NDAs.


Qualifications/Experience:

Qualifications

  • PhD in Analytical Chemistry, Drug Metabolism, Biochemistry, Chemistry, Pharmacology, or related subject area with 12+ years of drug development and proven experience in DMPK.
  • Proven record of excellence with 8+ years in leadership and management of analytical, DMPK, and pharmaceutical chemists.
  • Demonstrated record of driving drug discovery projects from hits to the selection of clinical candidates and the subsequent initiation of clinical trials.
  • Expert knowledge and hands on experience with state-of-the-art Analytical Chemistry, all DMPK concepts (i.e., preclinical pharmacokinetics, PK/PD relationships, metabolism, bioanalysis, and in vitro and in vivo techniques applying to these concepts), and pharmaceutical sciences.
  • Builds positive relationships with peers and cross-functionally with partners outside of the team to enable higher performance.
  • Experience in delivering effective analytical support to Discovery and Development Chemistry.
  • Excellent interpersonal, communication, and decision-making skills.
  • Demonstrated ability to manage external contractors to meet/exceed Company goals.
  • Must have strong negotiating skills and business oriented.

Our passion is anchored in rigorous and diligent scientific and clinical approaches to the discovery and development of novel mechanism therapeutics. With gratitude for the commitments and convictions of our employees who are inspired by the courage of patients we aim to serve, we believe Cytokinetics will continue to be a pioneering, values-driven, sustainable, fully integrated biopharmaceutical company.

 

Please visit our website at: www.cytokinetics.com

Cytokinetics is an Equal Opportunity Employer



Location: South San Francisco

Contact: Rebecca Orellana - rorellana@cytokinetics.com

Post Date: 4/5/2022 5:04:52 PM
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