View more job listings or post a job
Genentech Inc. Contractor Scientist–Drug Metabolism
Genentech, Inc. Associate Scientist / Scientist, Biotransformation and ADME of New Modality  
Genentech, Inc. Scientist / Sr. Scientist, Drug Metabolism and Pharmacokinetics  
Pliant Therapeutics, Inc. Senior Research Associate, DMPK
STEMSourcing LLC DIrector Pharmacometrics
Global Blood Therapeutics SCIENTIST – DMPK
DiCE Molecules Associate Director, Discovery DMPK
Agios Pharmaceuticals Senior Scientist, DMPK/Clinical Pharmacology
UC Davis - California Animal Health and Food Safety Laboratory System Job Title: Analytical Chemist Payroll Title: Staff Research Associate 3 (Exempt) Salary Range:  $4592.00-$7384.00/Month Appointment Type:  Career - 100%  
Post a job

Associate Director, Discovery DMPK

DiCE Molecules


We are currently seeking an Associate Director/Principle Scientist, Drug Metabolism and
Pharmacokinetics/Bioanalytical, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the qualitative and quantitative in vitro and in vivo PK/ADME bioanalytical assays. 

The candidate will be expected to collaborate with Medicinal Chemistry and Pharmacology to develop and execute assays/studies necessary to address key program DMPK issues in order to successfully advance research compounds into development.


Essential Functions:

 Provide scientific DMPK leadership and strategic direction to research project teams
 Provide scientific oversight of PK/ADME studies placed at CROs
 Execute/manage quantitative bioanalysis of plasma and other biological matrices to support
pharmacokinetic and in vitro ADME analyses of novel small molecule therapeutics
 May supervise associate-level DMPK scientists
 Conduct PK and PK/PD modeling using noncompartmental and compartmental models
 Organize and maintain research data
 Present data at project team meetings
 Ensure that high quality research reports are completed in a timely manner

Preferred Experience and Education:

 PhD in a scientific discipline or BS/MS with appropriate work experience
 7-10 years (PhD) or 12-15 years (BA/MS) of postgraduate experience in an industry research and/or development environment is preferred
 Strong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skills

Preferred Additional Skills:

 Should be familiar with ABI Analyst, Excel, WinNonlin Phoenix and Prism
 Prior success demonstrating strong leadership, collaboration and influence throughout the organization
 Prior management experience of Research Associates and/or Scientists is a plus
 Strong bioanalytical method development skills (HPLC and LC/MS/MS)
 Experience conducting microsomal, plasma and whole blood stability determinations, metabolite profiling, CYP and transporter inhibition studies, and plasma protein binding analyses
 Be able to work independently and in a cross-functional team environment
 Must have solid knowledge and demonstrated hands-on experience in qualitative and quantitative
bioanalysis and in vitro assay development
 Strong verbal, written communication and relationship skills including success managing external vendors
 Excellent interpersonal and organizational skills
 Engaged in LC/MS/MS instrument maintenance and repair
 Detail-oriented and have an in-depth understanding of industry trends
 Success operating in a fast-paced, dynamic environment
 Current US work authorization required
 Ability to travel domestically

Location: San Francisco Bay Area


Post Date: 1/27/2020 12:00:00 AM
©Pharmaceutical & BioScience Society, International; Last Modified: 3/28/2020; Admin Logon
Ads (in random order)
Submit a Text Ad
($250 for 2 months)

Hypha Discovery Experts in scalable synthesis & purification of drug metabolites, including CYP, AOX, FMO metabolites as well as O-, N-, acyl glucuronides & sulfates
Alturas Analytics, Inc. Expert GLP & non-GLP LC-MS/MS, GC-MS/MS bioanalytical & PK/TK analysis services of small & large molecules in any matrix. Discovery through phase IV.
Simulations Plus Intro & Advanced GastroPlus PBPK PBBM modeling workshops Feb. 24-28 in Redwood City, CA. Register today!
BioTether Sciences We provide bioanalytical testing services to characterize your large molecule drug, gene therapy, or drug-device combination product.
ReechPharma Bay Area (Newark) company, supporting clients with CUSTOMIZED FORMULATIONS that are soluble, stable, scalable & safer. Preclinical to post-marketing!
Submit a Text Ad